本片根据真实故事改编。
　　农村孩子石娃（赵强）自幼丧母，与父亲（江化霖）和姐姐（颜丹晨）相依为命的他长到七岁时，为生活所困的父亲再也拿不出足够的钱供他和姐姐同时读书，一把铜勺令成绩优异的姐姐辍学，父亲叮咛石娃好好读书。石娃上初中时，姐姐为给家中节省开支早早出嫁，并从男方出的彩礼钱中挤出一部分供他念书。懂事的石娃刻苦读书，在全国化学奥林匹克竞赛中夺得一等奖第三名的好成绩，并考取了省城师范学校，但此时父亲却在干活时不幸摔伤终瘫痪在床，为了照顾好父亲又不耽误学业，石娃决定背起父亲上学。

　　民国年间，为给久病不愈的曾老太太冲喜，京城大户曾家举全族之力娶曾孙媳妇瑞贞（哈辉 饰）进门，不料新人落地，老太太一命归西，喜事变成丧事。如今的曾家已不复昔日的辉煌，只剩下厉色内荏的空架子。长孙文清（程前 饰）整日无所事是，不待见妻子思懿（吕丽萍 饰），对寄人篱下的表妹愫方（黎静 饰）情有独钟。思懿碍于长孙媳地位，明知丈夫爱着别人也不便发作，免强支撑着这个外人看来所谓的京城大户。江泰（唐黎明 饰）寄居在丈人家，空怀满腔志愿没有施展空间。曾家故交袁任敢（石冼 饰）是个人类学家，这次他带女儿袁圆（关凌 饰）从海外归来暂住曾家，似乎带来一丝新鲜空气。曾霆虽说娶瑞贞为妻，但孩子气未脱的他对新来的袁圆更有好感......

　　在1997年的除夕夜，英国伦敦的人们都在准备迎接新年的到来，为新年的到来欢呼庆祝。此时一辆汽车失事撞毁了，港生（黎明 饰）和韵文（舒淇 饰）是车上的一对中年男女，他们在人们的欢呼声中逝去。经调查发现，原来他们是一对偷情的爱侣，由于各自都有家室，家中亲人大怒，只派了他们各 人的儿子及女儿处理后事。刚开始这两个年轻人都认为对方的父母破坏了自己的家庭幸福，各有怨恨。当他们翻查警方交给他们有关父母的资料的时候，才从照片、书信、日记等东西中，看到了他们父母当年美好的爱情故事……

　　不是冤家不聚头，刘元（葛优 饰）和李清（徐帆 饰）正应了这句话。他们在美国初遇，那时候，李清刚到美国，替一个台湾朋友看屋，就碰上了接待中国剧组的刘元。几番来回，二人有了些粗浅的了解。刘元给了李清一张机票，劝她回国，前途会比这里好。
　　李清却留在了美国，一年后还碰巧和刘元的车撞上了。机缘巧合，刘元让李清到他的旅行社工作，怎料旅行社搞非法移民的勾当，李清一身麻烦，一气之下叫刘元以后再也别联系自己。想不到，一年后他们重遇，又一起办起了补习班。
　　两人就这样反复的重聚分开。直到老去的某天，才有了一个契机，让他们互诉衷情。

　　农村青年冬子（施渝）为改变自己的命运，只身来到武汉投靠老乡高平（郭涛），成了一名被武汉人称作“扁担”的挑夫，挣钱仅够勉强度日。
　　高平为挣快钱，与人联合敲诈，不想中途被同伙打伤，伤愈后，他带冬子去歌舞厅找寻阮红（王彤），以期通过她找出同伙报仇。阮红被带到两人住处，与高平于一夜之间成了情人。接触过程中，冬子渐渐爱上阮红，但阮红更需要的是一个可以改变她命运的男人，然而高平的命运也同她及冬子一样，并不由自己控制。

　　日本第一通缉犯、恐怖组织“圣众之道”头脑吉永英明在香港被扣留，香港督察Ken（张智霖 饰）与女友Anita（舒淇 饰）在回家路程中偶遇吉永英明手下盗取化学品后遗弃的卡车在路面失控，Ken因此而卷入这次国际犯罪事件。为了引渡吉永，曾经在吉永手下吃过大亏的鹰见探员（泽田谦也 饰）一行通过领事馆试图与香港警方沟通，然而吉永的手下同时抵港，为了搭救吉永，恐怖分子用沙林毒气来威胁香港警方，为了保证香港作为金融中心的声誉，程督察（李绮红 饰）等警员尝试低调平息此事，并通缉擅自追踪圣众之道的Ken与鹰见。为了惩治罪犯，Ken二人却决定不惜一切代价……

　　In 2262, Earthforce Captain Elizabeth Lochley is appointed to command Babylon 5. The station grows in its role as a sanctuary for rogue telepaths running from the Psi Corps, resulting in conflict. G'Kar, former Narn ambassador to Babylon 5, becomes unwillingly a spiritual icon after a book is published that he wrote while incarcerated during the Narn-Centauri War. The Drakh, former allies of the Shadows who remained in the galaxy, take control of Regent Virini on Centauri Prime through a parasitic creature called a Keeper, then incite a war between the Centauri and the Interstellar Alliance, in order to isolate the Centauri from the Alliance and gain a malleable homeworld for themselves.
　　Centauri Prime is devastated by Narn and Drazi warships and Londo Mollari becomes emperor, accepting a Drakh Keeper under threat of the complete nuclear destruction of the planet. (Portions of the end of his reign are seen in various prescient visions throughout the series; they show Mollari and former nemesis (and later friend) G'Kar sixteen years in the future dying at each other's throats, seemingly out of their grudge. It is gradually revealed that there was a much more friendly subtext, with Mollari having become a slave to the drakh rule and being tired of life; his Drakh Keeper awakens and strangles G'Kar in return. Vir Cotto, Mollari's loyal and more moral aide, succeeds him as emperor, free of Drakh influence. Sheridan and Delenn marry and move to Minbar, along with the headquarters of the Interstellar Alliance. G'Kar leaves Babylon 5 to escape his unwanted fame and explore the rim. Garibaldi also marries and settles down on Mars. Most of the other main characters leave B5.
　　Nineteen years later on the verge of death, Sheridan takes a final trip to the obsolete Babylon 5 station before its decommissioning. Sheridan apparently dies but is claimed by the First Ones, who invite him to join them on a journey beyond the rim of the galaxy. Babylon 5 station is destroyed in a demolition shortly after Sheridan's departure, its existence no longer necessary as the Alliance has taken over its diplomatic purposes. This final episode features a cameo by Straczynski as the technician who switches off the lights before Babylon 5 is demolished.