在第一集解决了“毁灭钢眼博士”后，“神奇四侠”已经逐渐适应了新的身份，队员们的生活亦过得有滋有味 。里德（尤安·格瑞福德 Ioan Gruffudd 饰）和苏珊（杰西卡·阿尔芭 Jessica Alba 饰）终于步入教堂，然而，正当婚礼进行到一半时，突然狂风大作，一道银 色闪电在天空闪过。
　　里德忙叫“霹雳火”（克里斯·埃文斯 Chris Evans 饰）追上去看过究竟，熟料“霹雳火”完全不是对方对手，里德的担忧变成了现实：新的敌人出现了――“银影侠”（道格·琼斯 Doug Jones 饰）！
　　世界各地开始灾难不断。通过调查，苏珊发现“银影侠”只不过受“行星吞食者”盖拉克图斯所迫，帮其在宇宙寻找可供其吞食的星球，今次的目标正是――地球！“神奇四侠”又出动了，这次能否帮助可怜的“银影侠”、成功挽救地球？

　　公元2035年，人类被12只猴子军研制的一种病毒侵袭，大部分人类都在这场病毒灾难中死亡，只有少数人侥幸逃生，但也只能在阴暗的地下，苟且偷生。
　　科学家们决定派人穿越时光回到1996年追查12只猴子军的来历。囚徒詹姆斯·科尔(布鲁斯·威利斯 Bruce Willis 饰)被 挑选为志愿者。阴差阳错，科尔回到了1990年，当他向当时的人们描述未来的那场大灾难时，被当作精神病捉了起来并被医生凯瑟琳·雪莉（玛德琳·斯通 Madeleine Stowe 饰）诊断为精神分裂症。科尔在病友杰弗里·戈因斯帮助下逃脱，回到了未来。因为没查清12只猴子军的来历，科尔再次被派回了1996年。
　　科尔这次发现了12只猴子军的起源地在费城，他找到了医生凯瑟琳，二人一起展开了追查12只猴子军的冒险之旅!

　　A Medieval Knight resurrects to fulfill his vow and bestow a blood-thirst vengeance upon the kindred spirits of those who betrayed him long ago. In the course of one night, identities will be revealed, destinies met, and a poetic justice of the macabre maniacally served. Here lies a tale of passion, loyalty, deceit, betrayal...and revenge. They were Warriors. They were Crusaders. Under the leadership of the righteous GREGOIRE, this band of brothers in the Holy Order of the Knights Templar selflessly fought back-to-back, defending GOD and the "True Cross." Until one dark night of utter betrayal... Glorious was their victory that night, gold their find. The spoils were to be taken to their Grandmaster for use in furthering their "Cause." Yet greed had infected one of their number - RENAULT - and under the influence of the demon of lust, he embraced and fiendishly persuaded others to help him carry out his nefarious plan of betrayal. Among those whose hearts he blackened was the already resentful MENAS, envious of his brother MELKON, the man famed as being both the greatest swordsman in all of Europe and the right hand of Gregoire. The following morning Renault's heinous plot went into effect and Gregoire, Melkon and their beloved steward KOKO were ambushed and executed for purposes of greed. But as he lay dying, Gregoire vowed his revenge. Ten lifetimes of excess Renault and his murdering compatriots would enjoy. And then he would return to deliver their souls to Hell for all of eternity. Ten lifetimes of excess... The centuries pass and after 700 years, the allotted time of the evildoers nears culmination. One dark, stormy night, the Crusader, upon his steed, resurrects to execute his pledge of vengeance upon the now kindred spirits of those who victimized him so very long ago. The stage is set for retribution as an eclectic group assembles at a secluded manor home under the guise of a promised "fantasy weekend" to fulfill personal desires. JAKE, the "events coordinator" will have his hands full playing host to his young guests; CELINE, the alluring and promiscuous Eastern-European, ASHLEY, the contemptuous yet beautiful socialite, AMY, the innocent and meek girl-next-door, HURCOS, the predatory Middle-Eastern playboy, and JAPONIKO, the uninvited and mysterious Asian minimalist. SHAUNA, the abrasive Irish cook, and her cohort in crime BENOIT, the bone-idle English caretaker, along with the enigmatic PRIEST and the benevolent SHOPKEEPER, round out this unusual and extremely colorful cast of characters. Jake assigns the position of assistant recreational coordinator to Amy, and as she reads from an obscure storybook, the tale of Gregoire and his righteous band of Templar Knights animates, and the story of betrayal is reenacted for the guests. Blood will flow excessively as the cursed and unsuspecting kindred spirits meet their imminent destinies one-by-one during the Crusader's maniacal reprisal.

　　丹和他怀孕的妻子在山路上开车，却被坏人劫持。被坏人用枪指着头，夫妻俩与亡命徒斗智斗勇。

　　在本地小有盛名的少女侦探南茜•朱儿（艾玛•罗伯茨 饰），因为父亲的生意，离开了小镇，搬到洛杉矶生活。随着环境的改变，她也答应了爸爸，从此不再冒险破案，做一个普通的女孩儿。
　　巧合的是，朱儿一家的新宅正是神秘死亡的好莱坞著名女影星德丽娅•德雷克特生前的居所。自从德丽娅死后，这所宅子经常发生一些古怪的事件。这个神秘的地方以及女星离奇的死因又激起了朱儿的好奇心，她决定瞒着父亲，“重操旧业”。
　　在男友奈德•尼可森（马克斯•希尔洛特 饰）和新认识的小伙伴科奇（乔什•弗里特尔 饰）的帮助下，朱儿逐渐发现了一些线索，但与此同时她却收到了莫名的死亡威胁……

　　二十世纪70年代，旧金山出现了一个自称“十二宫”的杀人狂，杀人后，向媒体寄一封信，留下密码、线索，向警方挑衅，多次的阴差阳错使案件陷入僵局，警方渐渐束手无策。连环杀人案件也引起了《旧金山纪事报》的记者罗伯特（杰克•格兰恩哈尔 饰）和保罗（小罗伯特•唐尼 饰）的注意，他们在警察大卫（马克•普法洛 饰）的帮助下，开始调查这一系列的连环凶杀案件，在和“十二宫”杀手斗志斗勇的同时，他们个人的生活也面临了极大的挑战。

　　道格（贾斯汀•巴萨 Justin Bartha 饰）即将与女友结婚。婚礼前两天，道格与朋友菲尔（布莱德利•库珀 Bradley Cooper 饰）、西德（艾德•赫尔姆斯 Ed Helms 饰）和阿兰（扎克•加利费安纳基斯 Zach Galifianakis 饰）从洛杉矶驱车前往赌城拉斯维加斯为道格举办婚前单身派对，入住凯撒宫豪华套房。一晚过后，三人发现道格失踪，浴室里出现一只老虎，衣橱中多了一个婴儿，西德缺了一颗牙，窗外塔尖上插着席梦思床垫，菲尔戴着医院手环，西德口袋里有一张800美金收据，而他们的车也不知为何变成了警车。三人惊慌失措，完全无法记起昨晚发生过什么，却必须在24小时之内迅速解决谜团找到道格返回洛杉矶……

　　1943年8月，二战正是如火如荼之时。隶属美军的潜艇虎鲨号在返航途中接到命令，要求他们前去营救一艘遇袭英国军舰上及船上的幸存者。由于遭到鱼雷攻击，英国军舰上300多人几乎悉数遇难，只有3个人侥幸逃生，其中包括一名性感美丽的女护士克莱尔·佩基（奥莉维娅·威廉姆斯 Olivia Williams 饰）。克莱尔的到来让这群正处在青春壮年的美国军人兴奋不已，不过有些人却隐隐感到不安，他们相信女人上船会为潜艇带来灾难。
　　也许迷信并非空穴来风，自从幸存者到来后，虎鲨号便不断遭遇各种离奇故障，更遭到德军的猛烈攻击。然而诡异事件并未就此结束，随着磨难的涌现，隐藏的真相也渐渐浮出水面……

　　“黑蛇”（乌玛•瑟曼 Uma Thurman 饰）继续上一集未完的复仇之旅。探听得知，前比尔的贴身保镖“响尾蛇”洗手不干后住在得克萨斯州的奥斯汀。当她晚上悄悄溜到“响尾蛇”住的拖车上时，却中了埋伏，被“响尾蛇”用枪击中胸部并被麻醉了。
　　“响尾蛇”将“黑蛇”装到棺材里填埋 了。此时，“黑蛇”苏醒过来，运用她的师傅白眉老道所传授的功夫从棺材里脱身。当她回到“响尾蛇”所住的拖车时，发现“响尾蛇”和另一个追杀目标“加利福尼亚蛇”正在交易她随身携带的宝刀。打斗中，“加利福尼亚蛇”放出的巴曼蛇咬死了“响尾蛇”。
　　“黑蛇”终于见到比尔了，并揭开了自己满门被杀的真相。