La Última tells the story of Candela, a young woman who works at a logistics company and is pursuing her dream of becoming a singer. Her life changes when Fede Ariza, an important record company executive, hears her sing in a bar. That same night, Candela meets up with Diego, an old classmate from high school who is fighting to become a professional boxer. In their story, they will overcome obstacles and disappointment, and experience hope, love, and friendship.

　　1936年的马德里，一名理想主义医生庇护了一名受伤的间谍，并加入了长达数十年的反法西斯斗争，他的人生也从此改写。

　　一场诡异意外造成多数同学丧生，倖存的爱儿玛也失去记忆，她不仅得试著拼凑出当天的情况，还要设法想起自己的身分。

　　亚瑟从监狱被释放，继续他在尼莫点的研究。在那里，包括他女儿在内的科学家发现了一种能够火吧影院减缓气候变化的藻类。然而，一场谋杀让噩梦再次开始。